Estrogen makes mice more active

 https://www.cshl.edu/videos/estrogen-it-makes-a-mouse-move/

So it looks like I've been estrogenized since I was a kid. I can't be still. I just moved to Munich and I've gone on random foot trips all throughout the city almost every single day. I am the estrogen mouse:-)

Estrogen levels vary according to the time in the menstrual cycle https://en.wikipedia.org/wiki/Estrogen#/media/File:Estradiol_during_menstrual_cycle.png

This paper has a beautiful sentence about the two isoforms of estrogen.

https://journals.physiology.org/doi/full/10.1152/physrev.2001.81.4.1535

One important characteristic of ERβ seems to be its capacity to modulate the biological activity of ERα (388) in the sense that ERα is counteracted by ERβ as if ERα/ERβ would represent an example of the yin-yang principle.